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Three Lakes Consortium for PF (TLC4PF)

A multi-year initiative


Yale School of Medicine and University of Pittsburgh Department of Medicine


The Three Lakes Consortium for PF (TLC4PF) aims to accelerate therapies for this devastating disease. TLC4PF comprises two strategic workgroups – PF Connectome and PF Translation. These workgroups will work together to identify potential treatments for PF using artificial intelligence and cutting-edge single cell profiling technologies and to validate efficacy of the molecules with human tissue-based models. 

At least 10 institutions globally will be participating in the TLC4PF. Their contributions will establish pathways to the discovery, translation, and clinical testing of next generation therapies designed to stop and manage PF. 

The PF Connectome workgroup is led by Naftali Kaminski, MD. Dr. Kaminski is Professor of Medicine and Pharmacology and Chief of Pulmonology, Critical Care and Sleep Medicine at Yale University School of Medicine. The lead investigator for the PF Translation workgroup is Melanie Königshoff, MD, PhD. She is a visiting professor of medicine at the University of Pittsburgh School of Medicine.

Enlil Therapeutics

Three Lakes Foundation has provided funding to support Enlil Therapeutics in its quest to identify compounds that activate telomerase.

B4PF: Understanding Early Disease

To develop therapies that prevent the development of PF, it is essential to study the earliest aspects of disease pathogenesis.

A Global Collaboration for PF

Centre of Research Excellence in Pulmonary Fibrosis (CRE-PF) is a clinically focused research program funded by the Australian National Health and Medical Research Council.

Additional Programs

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