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Breath Biopsy for Early PF Detection



Owlstone and Brigham and Women's Hospital


Metabolic changes associated with IPF and interstitial lung abnormality (ILA) may lead to the production of unique, volatile, organic compounds (VOCs) detectable in breath. The aim of this study was to identify a diagnostic signature for early detection of PF by measuring compounds present in exhaled breath from patients with interstitial lung disease (ILD) and their relatives. 

Exhaled breath samples were collected at Brigham and Women’s Hospital using the Owlstone ReCIVA. Of the 129 distinct molecular features detected, three appeared to be predictors of IPF. Based on these results, it was predicted that some ILD subjects were more likely to have IPF than others, however, follow-up diagnosis is required for confirmation. 

The lead investigator for the study was Ivan Rosas, MD, who serves as Professor and Section Chief at Baylor College of Medicine. Jose Martinez Manzano, MD, was responsible for patient recruitment and sample collection. He works in Pulmonary and Critical Care Division at Brigham and Women’s Hospital. 

A poster presentation entitled Breath Biopsy® Biomarkers for IPF” was presented at the Breath Biopsy Conference in October 2021. The poster can be found in the Publications section of this website or you can click here.

Enlil Therapeutics

Three Lakes Foundation has provided funding to support Enlil Therapeutics in its quest to identify compounds that activate telomerase.

B4PF: Understanding Early Disease

To develop therapies that prevent the development of PF, it is essential to study the earliest aspects of disease pathogenesis.

A Global Collaboration for PF

Centre of Research Excellence in Pulmonary Fibrosis (CRE-PF) is a clinically focused research program funded by the Australian National Health and Medical Research Council.

Additional Programs

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